By default, ArcGIS portals (including ArcGIS Online) allow cross-domain requests using Cross-origin Resource Sharing (CORS). In the Esri portal that you use with Mobile Designer, if you have any domains configured in the Organization > Settings > Security > Allow Origins setting, then you must add the Mobile Designer server as an allowed origin.
In the Esri portal that you use with Mobile Designer, configure the Organization > Settings > Security > Allow Origins setting in any of the following ways:
•ArcGIS Online with SaaS Mobile Designer: If you use ArcGIS Online with SaaS Mobile Designer and your organization has configured the Allow Origins setting in ArcGIS Online, then you must add apps.vertigisstudio.com as an allowed origin.
•ArcGIS Online with On-Premises Mobile Designer: If you use ArcGIS Online with on-premises Mobile Designer and your organization has configured the Allow Origins setting in ArcGIS Online, then you must add your Mobile Designer server as an allowed origin.
•On-Premises Portal for ArcGIS with On-Premises Mobile Designer: If you use an on-premises Portal for ArcGIS with on-premises Mobile Designer, and your organization has configured the Allow Origins setting in your portal, then you must add your Mobile Designer server as an allowed origin.